The Science

The science is real.
So are the results.

Every ingredient in Lucent was chosen for one reason: published clinical evidence that it works — in the right form, at the dose that actually moves the needle, for the cellular depletion you came here to solve.

1,000mg Clinical-dose glutathione, matching published trial protocols

5 Clinically studied active ingredients

3 Glutathione pathways supported — synthesis, recycling, activity

3× Higher absorption from liposomal delivery vs. standard oral

Our Approach

Not one ingredient.
A complete system.

Most supplements hand you a single compound and call it done. But glutathione isn't a single-point problem. Your body has to make it, recycle it, and use it — and each of those three steps depends on a different cofactor. A glutathione capsule alone ignores two-thirds of the system, which is why so many people take it and feel nothing.

Lucent was formulated to support all three pathways at once: liposomal glutathione to directly replenish stores, resveratrol to switch on your body's own production, vitamin C and riboflavin to recycle spent glutathione back to active, and selenium to power the enzyme that puts it to work. The result is compound — each ingredient makes the others work better.

Liposomal L-Glutathione

1,000 mg — Clinical Daily Dose

The master antioxidant — delivered in the form proven to raise your body's stores.

★ Dose matched to the 1,000mg human trial

Liposomal glutathione capsules with white crystalline glutathione powder

What it does: Glutathione (GSH) is the body's master antioxidant — produced inside every cell, central to neutralizing free radicals, detoxifying the liver, and regenerating other antioxidants. Production declines with age and chronic stress. Standard oral glutathione has long been considered poorly absorbed because stomach acid degrades much of it before it reaches the bloodstream. Liposomal encapsulation wraps each molecule in a phospholipid layer — the same material as your cell membranes — protecting it through digestion so more reaches circulation.

Raises measured body glutathione stores in red blood cells, plasma, and lymphocytes
Improved skin elasticity and reduced wrinkle depth in a study of middle-aged women
Supports liver detoxification and cellular antioxidant defense
Replenishes the glutathione that depletes with age and oxidative load

Clinical Study — Body Stores at 1,000mg

Oral glutathione at 1,000 mg/day for six months significantly increased body glutathione stores — up to ~30–35% in some compartments — in a randomized, placebo-controlled trial.

A randomized, double-blind, placebo-controlled study of 54 adults compared 250 mg and 1,000 mg/day oral glutathione against placebo over six months. Both doses raised glutathione in blood, with the largest increases in erythrocytes, plasma, and lymphocytes at the 1,000 mg dose — the exact dose in Lucent.

Richie, J.P. Jr., et al. (2015). Randomized controlled trial of oral glutathione supplementation on body stores of glutathione. European Journal of Nutrition, 54(2), 251–263.

Clinical Study — Liposomal Delivery

Liposomal glutathione supplementation elevated body glutathione stores and improved markers of immune function within one to two weeks.

A trial of liposomal glutathione found increases in glutathione levels (in whole blood, erythrocytes, plasma) of up to ~40% in some measures, alongside enhanced natural killer cell cytotoxicity and lymphocyte function — direct evidence that the liposomal form raises circulating glutathione.

Sinha, R., et al. (2018). Oral supplementation with liposomal glutathione elevates body stores of glutathione and markers of immune function. European Journal of Clinical Nutrition, 72(1), 105–111.

Clinical Study — Skin, in Women

Oral glutathione improved skin elasticity and reduced wrinkles in middle-aged women over a 12-week randomized trial.

A randomized, double-blind, placebo-controlled study in middle-aged women found that oral glutathione (both reduced and oxidized forms) improved skin elasticity, reduced wrinkle measures, and influenced skin tone over 12 weeks — supporting glutathione's role in visible skin quality, not just internal markers.

Weschawalit, S., et al. (2017). Glutathione and its antiaging and antimelanogenic effects. Clinical, Cosmetic and Investigational Dermatology, 10, 147–153.

Resveratrol

100 mg — from Polygonum cuspidatum

Tells your cells to make more glutathione — at the level of gene expression.

★ Activates the body's own antioxidant production

Resveratrol from Polygonum cuspidatum root

What it does: Resveratrol is a polyphenol best known from the longevity literature. Beyond acting as an antioxidant itself, it activates two key cellular switches: Nrf2, the master regulator of antioxidant gene expression, and SIRT1, the sirtuin pathway tied to cellular stress resistance. Nrf2 activation upregulates the enzymes your body uses to synthesize its own glutathione — so resveratrol doesn't just add antioxidants, it tells your cells to make more of their own.

Increases intracellular glutathione synthesis via Nrf2 activation
Activates SIRT1 — the sirtuin pathway studied for cellular stress resistance
Provides direct polyphenol antioxidant and photoprotective support
Complements glutathione rather than competing with it

Mechanism Study — Glutathione Synthesis

Resveratrol increased intracellular glutathione by activating Nrf2 and upregulating glutathione-synthesizing enzymes, protecting cells against oxidative stress.

Researchers demonstrated that resveratrol induces glutathione biosynthesis through Nrf2 activation in human cells, raising glutathione levels and conferring protection against oxidative damage — the biological basis for pairing resveratrol with glutathione.

Kode, A., et al. (2008). Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against oxidative stress. American Journal of Physiology — Lung Cellular and Molecular Physiology, 294(3), L478–L488.

Research — Sirtuin / Longevity Pathway

Resveratrol activated the SIRT1 pathway and improved health and survival markers in a landmark study published in Nature.

A widely-cited study showed resveratrol shifted physiology toward patterns associated with longevity and improved metabolic health via the sirtuin pathway — the foundation of its place in the longevity literature.

Baur, J.A., et al. (2006). Resveratrol improves health and survival of mice on a high-calorie diet. Nature, 444(7117), 337–342.

Vitamin C (as Calcium Ascorbate)

50 mg — non-acidic, buffered form

Recycles spent glutathione back to active — and spares your existing stores.

★ Part of the glutathione–ascorbate cycle

Vitamin C as calcium ascorbate with Meyer lemon

What it does: Vitamin C and glutathione run a continuous recycling loop known as the glutathione–ascorbate cycle. When glutathione neutralizes a free radical it becomes oxidized; vitamin C helps regenerate it back to its active form — and glutathione returns the favor for vitamin C. The two spare and recycle each other, so adequate vitamin C means each dose of glutathione keeps working longer. We use calcium ascorbate, the non-acidic buffered form that's gentle on sensitive stomachs.

Regenerates oxidized glutathione back to its active state
Raised red blood cell glutathione in healthy adults in a controlled trial
Required cofactor for collagen synthesis
Non-acidic calcium ascorbate — easier on the stomach than ascorbic acid

Foundational Science — The GSH–Ascorbate Cycle

Vitamin C and glutathione function as a linked antioxidant system in which each regenerates and spares the other.

This foundational work established the biochemical interdependence of ascorbic acid and glutathione — explaining why vitamin C status directly affects how efficiently your body maintains active glutathione.

Meister, A. (1994). Glutathione–ascorbic acid antioxidant system in animals. Journal of Biological Chemistry, 269(13), 9397–9400.

Clinical Study — Raises Glutathione

Vitamin C supplementation significantly elevated red blood cell glutathione in healthy adults.

In a controlled study, vitamin C supplementation increased red blood cell glutathione concentration by nearly 50% — direct evidence that vitamin C helps maintain and elevate the body's glutathione pool.

Johnston, C.S., et al. (1993). Vitamin C elevates red blood cell glutathione in healthy adults. American Journal of Clinical Nutrition, 58(1), 103–105.

Selenium (as Selenomethionine)

55 mcg — bioavailable form

The mineral that powers the enzyme that actually puts glutathione to work.

★ Core of the glutathione peroxidase enzyme

What it does: Selenium is the catalytic core of glutathione peroxidase (GPx) — the enzyme that uses glutathione to neutralize hydrogen peroxide and lipid peroxides, converting free-radical damage into harmless water. Without adequate selenium, glutathione physically cannot do its primary antioxidant job. Selenomethionine is the well-absorbed organic form, preferred over cheaper inorganic selenite. Selenium also supports the enzymes that activate thyroid hormone.

Required cofactor for glutathione peroxidase enzyme activity
Enables glutathione to neutralize peroxides and oxidative damage
Supports thyroid hormone conversion
Selenomethionine — the bioavailable organic form, not selenite

Foundational Science — Selenium & GPx

The discovery that glutathione peroxidase is a selenium-dependent enzyme — establishing selenium as essential to glutathione's antioxidant function.

This landmark study identified selenium as a structural and catalytic component of glutathione peroxidase, the enzyme through which glutathione neutralizes peroxides. It is the reason a glutathione supplement without selenium leaves the system incomplete.

Rotruck, J.T., et al. (1973). Selenium: biochemical role as a component of glutathione peroxidase. Science, 179(4073), 588–590.

Research — Bioavailability & Thyroid

Selenomethionine is efficiently absorbed and incorporated, and selenium status supports the selenoenzymes involved in thyroid hormone metabolism.

Reviews of selenium biology confirm selenomethionine's superior incorporation versus inorganic forms and selenium's role in the deiodinase and glutathione-peroxidase selenoenzyme families — relevant to the thyroid and autoimmune context many customers come from.

Rayman, M.P. (2012). Selenium and human health. The Lancet, 379(9822), 1256–1268.

Riboflavin-5-Phosphate (B2)

5 mg — activated, methylated form

Regenerates glutathione — in the active B2 form MTHFR carriers can actually use.

★ Powers glutathione reductase + supports MTHFR

What it does: Riboflavin (vitamin B2), in its active FAD form, is the essential cofactor for glutathione reductase — the enzyme that regenerates oxidized glutathione (GSSG) back into its active, usable form (GSH). Without riboflavin, glutathione reductase can't keep glutathione recycled. We use riboflavin-5-phosphate, the pre-activated form that bypasses the liver conversion step — which matters for the roughly 1-in-4 people carrying MTHFR gene variants, for whom riboflavin is also a key cofactor.

Essential cofactor (as FAD) for glutathione reductase — the recycling enzyme
Activated riboflavin-5-phosphate — no liver conversion required
Supports MTHFR enzyme function in gene-variant carriers
Supports cellular energy production

Foundational Science — Glutathione Reductase

Riboflavin, as FAD, is the required cofactor for glutathione reductase — the enzyme that regenerates active glutathione from its oxidized form.

Riboflavin status directly determines glutathione reductase activity; in fact, the enzyme's response to added FAD is a standard clinical assay for riboflavin status. Inadequate riboflavin impairs the body's ability to recycle glutathione back to active.

Powers, H.J. (2003). Riboflavin (vitamin B-2) and health. American Journal of Clinical Nutrition, 77(6), 1352–1360.

Clinical Study — Riboflavin & MTHFR

Riboflavin produced measurable physiological effects specifically in individuals homozygous for the MTHFR 677C→T variant.

In a randomized trial, riboflavin supplementation lowered blood pressure specifically in adults with the MTHFR 677TT genotype — demonstrating that riboflavin is a functional cofactor for the MTHFR enzyme and that gene-variant carriers respond to it directly.

Horigan, G., et al. (2010). Riboflavin lowers blood pressure in cardiovascular disease patients homozygous for the 677C→T polymorphism in MTHFR. Journal of Hypertension, 28(3), 478–486.

The Full Stack

Five ingredients.
Three glutathione pathways. One capsule.

Glutathione isn't used up in one step — your body has to make it, recycle it, and put it to work, and each step needs a different cofactor. The reason Lucent delivers where single-ingredient glutathione falls short is that it covers all three pathways at once.

Synthesis — Make More

Liposomal glutathione directly replenishes your stores. Resveratrol activates Nrf2 to switch on the genes that build your own glutathione. You're not just adding it — you're producing more of it.

Glutathione · Resveratrol

Recycling — Regenerate

Every time glutathione neutralizes a free radical it goes oxidized. Vitamin C regenerates it through the glutathione–ascorbate cycle; riboflavin powers glutathione reductase, the enzyme that recycles it back to active.

Vitamin C · Riboflavin

III

Activity — Put It to Work

Selenium is the catalytic core of glutathione peroxidase — the enzyme that actually uses glutathione to neutralize oxidative damage. Without it, glutathione can't do its primary job.

Selenium

"The whole is greater than the sum of its parts" isn't marketing here — it's the pharmacology of a cofactor system. Remove any one ingredient and the system underperforms.

Full Transparency

Every dose. Every reason.

No proprietary blends. Here is exactly what's in each serving, why each dose was chosen, and how it maps to the research above.

Ingredient	Our Dose	Why This Dose
Liposomal L-Glutathione	1,000 mg	Matches the 1,000 mg arm of the Richie et al. (2015) trial — the dose that produced the largest increases in measured body glutathione stores. Matches trial dose
Resveratrol	100 mg	A meaningful daily dose to engage Nrf2-mediated glutathione synthesis and the sirtuin pathway, from the most-studied Polygonum cuspidatum source.
Vitamin C (Calcium Ascorbate)	50 mg	Buffered, non-acidic form chosen to sustain the glutathione–ascorbate recycling cycle without the stomach irritation of ascorbic acid.
Selenium (Selenomethionine)	55 mcg	Meets the adult daily requirement to fully support glutathione peroxidase activity, in the bioavailable organic form rather than selenite.
Riboflavin-5-Phosphate (B2)	5 mg	Activated form that drives glutathione reductase and bypasses the liver conversion step — relevant for MTHFR-variant carriers.

We Anticipated Your Skepticism

Real questions. Real answers.

These are the questions we'd want answered before buying a supplement — answered with the actual science, not PR language.

Does oral glutathione actually absorb, or is it destroyed in the stomach?

Raw oral glutathione is partly degraded by stomach acid — which is the entire reason IV clinics exist and why liposomal delivery matters. But the body-stores question has been answered directly: a randomized, placebo-controlled trial found 1,000 mg/day of oral glutathione raised measured glutathione in blood over six months, and a separate trial showed the liposomal form elevated glutathione stores within one to two weeks. Lucent uses the liposomal form at the 1,000 mg dose.
Richie et al. (2015), Eur J Nutr. · Sinha et al. (2018), Eur J Clin Nutr.

Is liposomal delivery real, or just a marketing word?

It's a real, characterized delivery technology. A liposome is a phospholipid sphere — the same material as your cell membranes — that encapsulates the compound and shields it through digestion. In the Sinha trial, the liposomal form produced measurable increases in circulating glutathione and immune-function markers. The mechanism is published and the body-store increases were measured in blood, not self-reported.
Sinha et al. (2018), Eur J Clin Nutr.

Are the doses actually strong enough to do anything?

The glutathione dose is the key one, and it's matched to the trial: 1,000 mg/day is the exact dose that produced the largest measured increase in body glutathione stores in the Richie study. Many glutathione products contain 100–250 mg — enough to print on a label, not enough to match the clinical evidence. If you've tried glutathione before and felt nothing, the dose may have been the reason.
Richie et al. (2015), Eur J Nutr.

Why the four cofactors — isn't glutathione enough on its own?

No, and this is the most important point on the page. Your body has to make glutathione (resveratrol switches on synthesis via Nrf2), recycle it (vitamin C and riboflavin regenerate the oxidized form), and use it (selenium powers glutathione peroxidase). A glutathione capsule alone supports only the first third of that system. The cofactors are why the formula works as a system rather than a single ingredient.
Kode et al. (2008) · Meister (1994) · Rotruck et al. (1973) · Powers (2003).

How long before I feel a difference?

It builds pathway by pathway. Many people notice steadier energy and sleep within the first one to two weeks. The clinical trials measuring body-store increases and skin changes ran six weeks to six months of consistent daily use. That's why we offer a 40-day money-back guarantee — enough time to feel the early changes risk-free.
Richie et al. (2015) · Weschawalit et al. (2017).

Is it safe to take every day, long-term?

Glutathione is a compound your body already produces in every cell, and the cofactors are at nutritional doses. Across the cited trials, glutathione and these cofactors were well tolerated with adverse-event profiles comparable to placebo. As with any supplement, if you're pregnant, nursing, have a medical condition, or take prescription medications, talk to your healthcare provider first.

You've read the science

Now feel the difference.

Five clinically studied ingredients. One clinical-dose liposomal capsule. The complete glutathione system — backed by the research above and our 40-day money-back guarantee.

40-Day Money-Back Guarantee · Third-Party Tested Every Batch · Free US Shipping

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. The studies referenced investigate individual ingredients and are provided for educational purposes; they are not claims about this specific product. Talk to your healthcare professional before use if you are pregnant, nursing, have a medical condition, or take medications.

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The science is real.
So are the results.